Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
Targeting defects in metabolism is an underutilized strategy for the treatment of cancer.Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers.To assess the metabolic effects that arise from acute and chronic arginine starvation in A