ARGININE DEPRIVATION INHIBITS THE WARBURG EFFECT AND UPREGULATES GLUTAMINE ANAPLEROSIS AND SERINE BIOSYNTHESIS IN ASS1-DEFICIENT CANCERS

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Targeting defects in metabolism is an underutilized strategy for the treatment of cancer.Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers.To assess the metabolic effects that arise from acute and chronic arginine starvation in A

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Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells

Jinjing Wu,* Yanli Yang,* Yafen Gao, Zhaoqi Wang, Jun Ma Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University-Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun MaDepartment of Anesthesiology, Beijing Anzh

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